CDC Updates Recommendations for MMRV Vaccination
When it was first licensed in 2005, Merck & Co.’s MMRV vaccine, which is marketed as ProQuad, was preferred by the ACIP for both the first and second doses, rather than separate injections of MMR and varicella vaccine.
However, the ACIP issued updated recommendations in February 2008 — stating no preference for the use of MMRV vaccine versus the two component vaccines — after preliminary data from two studies showed an increased risk for fever and febrile seizures five-12 days after vaccination among children ages 12-23 months who had received their first dose as the combination MMRV vaccine compared with children who received their first dose as separate injections of MMR and varicella vaccines.
Temte, a professor in the department of family medicine at the University of Wisconsin School of Medicine and Public Health, Madison, said the absolute risk of febrile seizure after measles, mumps, rubella and varicella vaccination is low. However, he said, the relative risk with use of the quadrivalent MMRV vaccine is double that associated with MMR plus varicella in separate injections when administering the first dose to children 12-15 months old.
Data from postlicensure studies do not suggest a similar risk for children ages 4-6 years receiving a second dose. Thus, the ACIP’s updated recommendations are as follows:
- For the first dose at age 12-47 months, either the trivalent MMR vaccine and varicella vaccine can be given in separate injections, or the quadrivalent MMRV vaccine may be used. Clinicians considering MMRV vaccine administration should discuss the benefits and risks of both vaccination options with parents. Unless parents express a preference for MMRV vaccine, the CDC recommends that MMR vaccine and varicella vaccine should be administered for the first dose in this age group.
- For the second dose at age 15 months to 12 years, and for the first dose in children ages 4 years or older, use of MMRV vaccine generally is preferred rather than separate injections of MMR vaccine and varicella vaccine. Considerations should include clinician assessment, patient preference and the potential for adverse events.
- Children with a personal or family history of seizures of any etiology generally should be vaccinated with MMR vaccine and varicella vaccine.